In 2010, he had a small role in The Twilight Saga: Eclipse as Royce King. He appeared in HBO's Boardwalk Empire as Richard Harrow, a severely disfigured World War I marksman turned gangster. On 16 December 2010, it was announced Huston would be made a series regular after appearing in five episodes of the first season.
After this he went on to be directed by Al Pacino in the 2011 film Wilde Salome and to having starring roles in Not Fade Away, Two Jacks and Night Train to Lisbon. In 2012, he played the part of narrator on avant-garde musician John Zorn's album A Vision in Blakelight, an homage to william Blake.
Huston began dating American model Shannan Click in 2011. Huston and Click have one daughter, Sage Lavinia Huston, born on 6 April 2013 in New York City, and one son, Cypress Night Huston, born in January 2016.