Her transition to the field of acting began after landing a role in Allison Anders's Grace of My Heart. Since her premiere role, De Niro has worked with and trained under Larry Moss, author of the acting guide, Intent to Live, and Susan Batson of The Black Nexxus Acting Studio. With the turn of the millennium, De Niro set her sights on writing and directing her first film, Girls and Dolls. This documentary examined a young stylist's obsession with her dolls, and won De Niro the Best Directorial Debut Award at the New York Independent Film/Video Festival in 2001.
More recently De Niro's endeavors have led her back to Italy, where she worked on her latest film. Since 2006, she has been the spokesperson for the Kageno Orphan Sponsorship Program, which helps provide care for orphaned children in Kageno villages. De Niro currently lives in New York City with her son.