Using his German language skills, her Father first worked for the German electronics company AEG and then in 1952, borrowing funds from a German friend, purchased the construction company Construcciones y Reparaciones S.A. which he renamed Construcciones y Contratas S.A. (CYCSA). He slowly built the company, carefully cultivating relationships during the precarious Franco era, and when Spain experienced a construction boom in the early 1960s, the company flourished.
Alicia was born in Madrid (Spain) in 1954, the second and youngest daughter (after Esther, born in 1953) of Ernesto Koplowitz Sternberg, a Jewish businessman from Upper Silesia (Germany) who settled down in Spain to escape the increasing German Nazi persecution in the early-1930s, and Esther Romero de Juseu y Armenteros, a Spanish aristocrat. (Alicia and Esther inherited their titles from their mother. Alicia is Marquesa de Bellavista and Marquesa del Real Socorro while Esther was Marquesa de Casa Peñalver, a title now inherited by one of her daughters.) Her parents married in 1950 in a Catholic ceremony.
Her Cuban-born mother, Esther Romero de Juseu y Armenteros (died 1968), started a legal battle to obtained the Marquisate of El Real Socorro, which ended in 1971 with Koplowitz gaining the nobiliary title; her sister Esther obtained in court in 1988 the County of Peñalver.
In 1969, Alicia's sister Esther married Alberto Alcocer and six months later, Alicia married Alberto Alcocer's cousin Alberto Cortina, the son of Pedro Cortina Mauri, foreign minister during the Franco period and founder of the beer brand San Miguel. The sisters gave up their board seats to their husbands and the "Albertos", as they were known, made the firm grow spectacularly from 1973 onwards and Diversified acquiring real estate, Banco Zaragozano, and 47 percent of Catalonia construction firm Fomento de Obras y Construcciones SA (FOCSA).
In 1990, Alicia divorced Alberto Cortina after he was photographed by paparazzi in 1989 with another woman (Marta Chávarri, then wife of Fernando Falcó, marqués de Cubas, who Esther would later marry in 2003). At the same time, Esther also found that her husband was having an affair and divorced six months later. In 1990, the sisters returned to the board of CYCSA, filling the seats vacated by their husbands. Their husbands received ownership of the Banco Zaragozano as part of the divorce settlement.
In 1992, CYCSA merged with 'Fomento de Obras y Construcciones, S.A. (FOCSA) forming the largest construction company in Spain. The company was renamed Fomento de Construcciones y Contratas S.A. (FCC). In 1998, Alicia sold her 28.26% stake in FCC to her sister Esther for 871 million euro. When Alicia left FCC in 1998, FCC was the largest construction and services company in Spain with nearly the sales of the next largest. In 2012, FCC had dropped to fifth largest in Spain while its competitor Grupo ACS (with the sisters' ex-husbands Alberto Cortina & Alberto Alcocer among its largest shareholders) is now the largest construction and services company in the world.
She has created two foundations: Fundación Vida y Esperanza (in 1994), that helps children, adolescents and young adults with social, family and financial problems with housing, education and work. The foundation now has approximately 100 people receiving full-time aid in Spain. Through a different branch of Vida y Esperanza she also gives housing and support to the elderly, helps people with special needs and works with other foundations.
In 1998, Alicia created Omega Capital, a venture capital firm specializing in growth. Omega Capital is an investment company 100% owned by Alicia Koplowitz. The first investment in funds of hedge funds was made in 1999.
Among her distinctions and awards, she was awarded the Gran Cruz de la Orden del Mérito Civil (May 2003), Chevalier de La Légion d'honneur of France (Knight of the Legion of Honour, of France), the prize for the recognition of her career from the State of Madrid in 2007 (Premio Persona Singular de la Comunidad de Madrid), the Gold Medal from the Spanish State in 2009 and the Gold Medal from the Red Cross in 2013.
Alicia Koplowitz also promoted, built and donated to the State the largest hospital in Europe specialized in multiple sclerosis in 2004 (Alicia Koplowitz Multiple Sclerosis Hospital).
Through her charitable foundation Fundación Alicia Koplowitz she sends Spanish fellows to research in child psychiatry in England and the U.S. at places like King's College, Columbia University's Medical Center or Stanford University. These fellowships cover the full research, housing and salary for 2 to 4 years and then help the fellow seek employment at a top institution when they return to Spain. The Foundation also organizes every year the largest convention for psychiatry in Spain where top scientist from all over the world come during one week to give lectures and make round tables and debates. In 2009 she was named an honorary member of the Spanish Society of Psychiatrists for her efforts to promote the study and development of child and adolescent psychiatry. Thanks to her efforts, the Spanish State recognized child and adolescent psychiatry as different specialization within general psychiatry in Spain.
In March 2017 she lost in court the right to be called the Marquise of Bellavista after being sued by her Cuban-American distant cousin María Elena de Cárdenas y González, aged 97. The same month De Cárdenas also won in the Spanish courts the marquisate of Almendares from another Cuban man, meanwhile in the previous month (February 2017), she gained the marquisate of Campo Florido from Koplowitz's niece, Alicia Alcocer-Koplowitz.
She is a member of several organizations, universities and foundations such as Member of the Board of the following organizations: L’Union Centrale des Arts Décoratifs "UCAD" de France, Christie's Auction House, The Shimon Peres Center for Peace, Guggenheim Museum, Prado Museum and The Prince of Asturias Foundation and Prize. She is also a member of the Board of trustees of University Charles III of Spain.