After graduating from Liberty University in 1993 with a degree in Business, Bream returned to Tallahassee and attended law school at Florida State University. She interned with Florida Congressman Bill McCollum, in the US House of Representatives. McCollum would later become the Florida Attorney General. While at law school at Florida State, she won the Miss Florida USA pageant (1995) and placed fourth in the Miss USA 1995 pageant.
In 2001, she moved to Charlotte, North Carolina, becoming the evening and late-night news reporter for the CBS affiliate, WBTV. In 2004, after three years at WBTV, Bream joined Washington D.C.'s NBC affiliate WRC-TV. At WRC-TV, she was a weekend anchor and covered general assignments.
While at WRC-TV, Bream met Brit Hume, who was the managing Editor of the Fox News Channel's Washington bureau. With his encouragement, she submitted audition tapes to Fox News. Bream joined the Fox News Channel in November 2007, and is based in the network's Washington, D.C. bureau. She then became the anchor/host of Fox News @ Night.