In late 2004, Randi's brother Mark asked her to join him at his startup Facebook, which he said was understaffed with people willing to travel and who could explain his vision. Randi took a position that required relocation and a cut in pay but with stock options. She has stated that she initially thought this was a temporary position that might last six months. Once she was in Silicon Valley and part of the innovation-driven community, she became fascinated with the possibilities and remained for ten years.
Adopting a politically neutral stance, Zuckerberg told the Wall Street Journal that her Facebook Journalist team was treated at the DNC "like rock stars". On the evening of November 2, 2010, Zuckerberg worked at a "town hall" assembled by ABC News as part of its television coverage of the U.S. national midterm elections. The seven-hour event was webcast in its entirety, on both Facebook and the ABC website.
In 2011 Zuckerberg advocated for the abolition of anonymity on the Internet to protect children and young adults from cyber-bullying. Zuckerberg explained how anonymity is protective for perpetrators.
Zuckerberg is the author of Spark Your Career in Advertising. In September 2013, she released her first books with HarperCollins, an adult non-fiction book titled Dot Complicated and a children’s picture book called Dot.
Zuckerberg appeared on the Today Show on January 26, 2016 in a segment entitled "2016 Netiquette" in which she discussed modern day etiquette on the Internet.