Greutert was the film Editor for The Strangers (2008), Room 6 (2006), and Journey to the End of the Night (2006). He was also the Editor of the Saw series for the first five films, as well as the last, Jigsaw (2017 film). He made his feature directorial debut with Saw VI, which was released on October 23, 2009.
Greutert was signed on to direct Paranormal Activity 2, but he was forced off the project and onto Saw 3D after Twisted Pictures (production company behind the Saw films) exercised a "contractual clause" in his contract. Tod Williams replaced him as Director for Paranormal Activity 2. Saw 3D was released on October 29, 2010.
He also directed the horror film Jessabelle for Producer Jason Blum and Lionsgate, which was released on November 7, 2014.
He also directed the 2015 horror film Visions, starring Isla Fisher, Anson Mount, Gilliam Jacobs, Jim Parsons, and Eva Longoria, also for Producer Jason Blum.
Greutert has also completed a new thriller entitled Jackals, starring Stephen Dorff, Johnathon Schaech and Deborah Kara Unger, which was released in 2017. He also returned to the Saw franchise by editing the 2017 entry Jigsaw.