Wyss served on the board of trustees of the National Outdoor Leadership School and was a member of the board of Directors for the Wyss Foundation In 2007, Wyss and her husband, Ed Jaramillo, established the LOR Foundation, a grant-making organization dedicated to improving livability in rural communities across the Intermountain West through community-driven conservation.
Wyss served on the board of Directors of Synthes from 2008 to 2012, when it was sold to Johnson & Johnson. She co-founded the Twirl Toy Store in Taos, New Mexico. She was also a co-founder of the Golden Willows Retreat, a bereavement center in Arroyo Hondo, New Mexico. In 2007, Wyss and her husband, Ed Jaramillo, established the LOR Foundation.
As of October 2015, she had a net worth of US$1.85 billion.