In 1987 with Yvan Vindevogel, he founded Omega Pharma a Belgian pharmaceuticals company that grew rapidly and in 2006 employed three thousand people whilst operating in thirty countries. He remained Chief Executive Officer of Omega Pharma until 30 September 2006 returning to the post in March 2008. Whilst his Business profile represents considerable achievement there have been high publicised failures that include the launch of Omega Pharma's E-Waves phone Chip in 2008. It was withdrawn shortly after release as it did not work.
In 2007, he was featured as a member of the jury in the television show De bedenkers. In 2013 he became the major shareholder and chairman of K V Oostende. Five years later, on 20 December 2017, he bought RSC Anderlecht.