Yasuko Matsuyuki was born in 1972 in Tosu, Saga. In 1989, while she was in high school, Matsuyuki won a Non-no fashion magazine contest. After graduating from Tosu Commercial High School, she moved to Tokyo and started her career as a model.
In 1991, Matsuyuki made her film debut in the TV drama series "Nekketsu Shinnyū Shain Sengen". In 1993, she played an outgoing leading role in the manga based drama series "Shiratori Reiko de Gozaimasu!". That role made a big impact on the drama scene and established her career as an Actress.
In 1998, after a 2-year relationship, Matsuyuki married Guitarist Gaku Kadowaki (門脇 学). She had a baby boy in 2001, but got divorced in 2005.