In 1984, Lo began investing in Shanghai and built a hotel in partnership with the Shanghainese Communist Youth League. The Tiananmen Square crisis caused occupancy to plunge, and the league could not repay its construction loan. Lo assisted the league in dealing with the loan: Han Zheng was the Youth League secretary at the time, and is now mayor of Shanghai.
In 1995, he bought his first cement plant in Chongqing, which has enabled the Shui On Group to become one of China's top three cement companies. Under Lo's direction, the Shui On Group is carrying out property development projects in other Chinese cities, such as Wuhan, Dalian, Foshan and Hangzhou, as well as Chongqing.
Vincent Lo and his current wife Loletta Chu married at 27 November 2008.