Tsai was born in 1957, in Datong District, Taipei, the son of Tsai A-Shi, who founded a canned fish Business in 1962.
He lives in Shanghai. His older son, Kevin Tsai runs the family's media empire of TV stations and newspapers. His younger son Matthew Tsai (Tsai Wang-Chia, born 1984) is the chief operating officer of Want Want China.
Tsai succeeded his Father as chairman of Want Want in 1987.
According to Forbes, Tsai Eng-meng has a net worth of $5.9 billion, as of January 2017.