Patrick has appeared in Playboy and Penthouse, where she was the "Pet of the Month" for February 2000 and was selected as "Pet of the Year" runner-up. In 2003, Patrick became the masthead publisher of Genesis.
After a three-year relationship, Patrick married musician and fellow porn actor Evan Seinfeld in a small ceremony, in Las Vegas on January 9, 2004, where they were attending the 2004 AVN Awards show. On September 30, 2009, the couple announced that they were ending their marriage. Tera remains sole owner of her production company, TeraVision Inc.
One of Patrick's earliest projects was the launch of an herbal product called Python for men and Naughty for women 2005.
In 2006, Patrick and her then-husband, Evan Seinfeld, launched a talent agency representing Models and actors. According to a quote on the agency's website, Patrick's goal "is to help girls (and guys) in the Business to be treated with respect, and realize their true potential...." Additionally, she owns a production company called "Teravision," which along with Vivid Video released its first feature, Desperate, starring Patrick and Seinfeld. In April 2006, it was announced that she would host the Exxxotica Miami convention.
In April 2007, Patrick and her production company, Teravision INC, filed a lawsuit against Jenna Jameson and Playboy Enterprises (the new owners of Club Jenna) for failing to properly account for and pay royalties on money earned by Patrick's Web site clubtera.com.
In 2008, Patrick began hosting the Playboy TV erotic instructional show, School of Sex. She was also the host for 25th AVN Awards ceremony.
Patrick's memoir, Sinner Takes All, co-written by Journalist and author Carrie Borzillo, was published by Penguin imprint Gotham Books on January 5, 2010. The book chronicles Patrick's path to stardom, along with various other life experiences she had along the way. During the writing process, which she describes as "cathartic", Patrick discusses how she and her mother repaired their relationship, and how she addressed problems within her relationship with her former husband, Evan Seinfeld. Patrick commented, "I wanted the book to end happily. I knew there were problems with our marriage obviously, and the decision to leave him came about quite suddenly."
In January 2013, Patrick hosted the annual XBIZ Awards.