Sofia Hublitz made her debut television appearance in 2013, where she was one of the contestants on MasterChef Junior, finishing in 8th place. Despite only being on the show for three episodes, she became popular with viewers.
In 2014, Hublitz landed the role of Danielle Hoffman in two episodes of the American television series Louie. She followed this in 2016 with an appearance as the "Young" Sylvia in a single episode of the American television series Horace and Pete. In 2017, Hublitz landed her first major role as Charlotte Byrde, the daughter of financial planner Marty Byrde played by Jason Bateman, and mom played by Laura Linney, in the American television series Ozark, where the family from Chicago find themselves involved in Business with a large Mexican drug cartel. Hublitz also acts alongside co-stars Julia Garner and Skylar Gaertner.
In 2016, Hublitz signed up with the United Talent Agency (UTA)