Van Dyke's professional acting career began after graduating from high school when he became involved with the theatre program at Moorpark College in California. He launched his television career as the smaller recurring character of Alex Smith, a medical student, on the CBS television show, Diagnosis: Murder, appearing in a total of 14 episodes. In 2002, he starred in the musical Annie.
In the summer of 2007, Shane rejoined his grandfather and father in a series of Hallmark Channel Original Movies titled Murder 101. Around the same period, he also co-starred in the Hallmark mini-series, Shark Swarm, opposite John Schneider and Daryl Hannah.
As of 2009, Van Dyke resides in Los Angeles and is a film and television faculty member with Hollywood for Kids.
In July 2013, Van Dyke appeared as Greg, a lifeguard in the SyFy film "Supershark" about a giant shark released from stone by an oil-drilling rig off the California coast.