In the early 1990s, she was the vocalist for Hollywood band Never on Sunday. She went solo, and in 1995 released the CD Orphan Child, which contained rerecorded songs from her previous band. Her debut DVD release, however, which Saint directed and produced, was The Underground Personality Tapes in 2003. She toured in England, including performing at the Leeds and Reading festivals. Blog Critics called Saint "the next huge thing" and "PJ Harvey crossed with Sophia Coppola."
She performed a song for the 1999 movie The Criminal, starring Steven Mackintosh, and a song for the 2002 film The Hot Chick, starring actor Rob Schneider.
Also in 2004, Saint, who's known for shopping for her clothes at thrift stores, launched her own clothing line titled Trash Couture with her dresses numbered and individually named ("Chaos," "Aquarius" and "Glitch"). MK Magazine described the line as "one-of-a-kind dresses made from black plastic trash bags."
The San Francisco Weekly wrote that during her 2005 European tour, Saint's belongings were stolen, which the paper said, "may have been the best thing that ever happened to her. ... Her slashed, duct-taped, hand-painted 'Trash Couture' creations were such a hit that she now sells them online."
She co-starred, playing the role of Lillith, in the 2008 film Zombie Strippers, written and directed by Jay Lee.
An only child whose father died when she was 2, Saint was raised in Southern California by her mother. She has one son, Jackson, born to Saint and husband Josh Evans in December 2010.
In 2014, filming completed in Las Vegas for Death in the Desert, a full-length movie in which Saint plays the character Corey and performs an original song by record Producer Chris Goss. Saint, an executive Producer on the film, which is directed and produced by her husband, Evans, stars Michael Madsen, Shayla Beesley and Paz de la Huerta.