Estevez's movies include That Was Then... This Is Now (1985) and Cadence (1990). In Cadence, he played a sycophantic "spineless corporal" to the stockade's commanding officer. Estevez was disguised in Cadence as a funny guard who wore glasses and "his hat most of the time" to prevent being recognized as Charlie Sheen's brother.
In 1992, Estevez appeared in The Last P.O.W.? The Bobby Garwood Story.
In 2010, Estevez approached Michael Ritchie about staging a play, The Subject Was Roses, at the Mark Taper Forum on the behalf of the production company Estevez runs for Martin Sheen called Estevez Sheen Productions. Martin Sheen created the play's Timmy on Broadway in 1964 and wanted to revisit it as Timmy's dad, John. In collaboration with Ritchie and Sheen, Estevez arranged for Brian Geraghty to play a role with Neil Pepe as the Director. The play opened on February 21, 2010, with Estevez in attendance. A 2011 Estevez Sheen Productions project was The Way with James Nesbitt written and directed by Emilio Estevez and starring Martin Sheen.
Since 2012, Estevez is co-producing Anger Management (TV series) with his brother Charlie Sheen, on FX.