After the war, Beisheim went into Business. The first Metro Market, opened in November 1963 in Essen-Altenessen. On 10 January 2004, Beisheim Center was officially opened on the North West side of Potsdamer Platz in Berlin, built for 463 million euros, and including the Ritz-Carlton and Marriott chains.
In 2009, he sold 5.2% of the shares of Metro AG to various national and international investors; a further 3.1% could be sold. The WHU-Otto Beisheim School of Management, in Koblenz is named after him.