In 1964, Pryor was an original cast member of the new soap opera Another World, playing Tom Baxter until the character was killed off after six months. In 1973 Pryor was the second actor to play the role of P.I. Joel Gantry on The Edge of Night. For several years in the late 1990s and early 2000s, he played the role of Victor Collins on General Hospital and its spin-off, Port Charles.
His early film credits include appearances in The Happy Hooker (1975), Smile (1975), and as nervous college professor Samuel Graves in the 1976 cult film The Gumball Rally. Notable film credits included appearing alongside william Holden and Lee Grant in Damien: Omen II (1978), as one of the sick passengers in Airplane! (1980), the role of Joel Goodson (Tom Cruise)'s father in the hit movie Risky Business (1983), and as Julian Wells' father in Less Than Zero (1987). His other film credits include The Falcon and the Snowman (1985), Pacific Heights (1990), Executive Decision (1996), The Chamber (1996) and Collateral Damage (2002).
Pryor has been married to Actress Christine Belford since July 1993.