Missy first reached the public eye when she and Bam starred in the MTV reality show Bam's Unholy Union. The show documented the weeks leading up to the couple's wedding. During the filming of the series she was approached by Playboy to pose nude with Bam as a guest Photographer, and she obliged, though reluctantly, as was chronicled on the show. Missy and Bam married on February 3, 2007, at the Loews Hotel in downtown Philadelphia.
In October 2010, Margera told Howard Stern he and Missy were living in separate cities, they meet once a week and Missy knows about his girlfriend in San Francisco and another in West Chester. In 2011, the two were spotted together following the death of Margera's best friend and Jackass co-star, Ryan Dunn.