Since 1993, Mikhail Abyzov worked as a top manager in different Russian fuel and power sector companies.
In 1998, Abyzov was appointed by the vice-president of the board of Directors of Novosibirskenergo. The same year, Abyzov was appointed by a member of the board and the chief of the Department of Investment Policy and Business-Projects of RAO UES. In 1999, he became the vice-president of board of RAO UES. In 2004, in connection with the change of the organizational structure of RAO UES, Abyzov was appointed by a member of the Board of the RAO and operating Director business-unit. Since June, 2003, Abyzov has been the Chairman of the Board of Directors of RAO UES municipal systems. Since July, 2005, Abyzov has been the general Director of Joint-Stock Company UK Kuzbassrazrezugol. Also, since April, 2006, Abyzov has been the Chairman of the Board of Directors of British coal company Power Fuel. In July 2007, Abyzov received a position as Chairman of the Board of Directors in E4 Group. Also, since August, 2007, Abyzov has been the Chairman of the Board of Directors for Mostotrest.
Mikhail Abyzov graduated from the Sholokhov Moscow State Open Pedagogical University (now -Sholokhov Moscow State University for Humanities) in 2000.
In May 2012, he was appointed as Minister for Open Government affairs in Dmitry Medvedev's Cabinet, as the only responsible for Open Government Affairs Affairs in Russia.