Ilitch and her husband have seven children: Christopher Paul Ilitch (born June 1965) is CEO and President of Ilitch Holdings, Inc.; Denise D. Ilitch (born November 1955) is an attorney and former co-president, with her brother, of Ilitch Holdings. Other children are Ronald "Ron" Tyrus Ilitch, Michael C. Ilitch, Jr., Lisa M. Ilitch Murray, Atanas Ilitch (born Thomas Ilitch) and Carole M. Ilitch. Ron Ilitch was found dead in his hotel room in February 2018 at the age of 61. This means now six out of seven children remain.
In 1985, Ilitch and her husband established the Little Caesars Love Kitchen Foundation, which consists of a mobile pizza restaurant. The Love Kitchen has fed more than 2 million people, aiding the hungry and disaster victims across the U.S. and Canada. Three Presidents, President Ronald Reagan, President George Bush Sr, and President Bill Clinton have recognized the work of the Love Kitchen.
The Detroit Red Wings have won four Stanley Cups under Ilitch family ownership: 1997, 1998, 2002, and 2008. Marian Ilitch and three daughters are among only 12 women to have had their names engraved on the trophy.
Ilitch served as vice chairwoman and secretary-treasurer of all of her family's various holdings until 1999, when Ilitch Holdings, Inc. was formed as the parent company for her family's widespread interests. She became chairwoman upon her husband's death.
One of the original Investors in Detroit's MotorCity Casino, Ilitch realized an opportunity to purchase total interest in the casino resort complex from various minor stakeholders and Mandalay Resort Group in 2005. Michigan Gaming laws prohibit one company from owning more than one Detroit casino property. With Ilitch as owner, MotorCity Casino is reportedly one of the largest independently owned casino enterprises in the United States—likely the largest woman-owned casino in the U.S.
Mike Ilitch's Detroit Tigers, a baseball team, logged losing records in 12 out of 13 seasons but turned the team around in 2006. They made the playoffs for the first time since 1987. The Ilitches successfully spearheaded a public/private partnership with the taxpayers of the greater Detroit area to build a new home for the Tigers in downtown Detroit. The $300 million plus Comerica Park opened in April 2000. Ilitch Holdings, Inc. manages the stadium and parking.