Famous for her oil paintings of doe-eyed characters, Keane was one of the most popular and commercially successful artists of the 1960s. Her paintings, which include "The First Grail," "Vanity," and "Two Siamese," typically feature images of children, animals, and women.
When she was just ten years old, she created her first painting-- an image of two young girls -- and presented it to her grandmother as a gift. She later trained at both the Watkins Art Institute (in Nashville, Tennessee) and the Traphagen School of Design (in New York, New York).
In the 1960s, she sued her ex-husband, Walter Keane, for having taken credit for her paintings for several years. Keane was her second husband; she was previously married to Frank Richard Ulbrich (with whom she has a daughter), and in her later life, she married Sports Journalist Dan McGuire.
She is portrayed by Actress Amy Adams in the 2014