In 2012, Deutch played a ghost-hunting reality show co-host Tech Kelli in video game Mystery Case Files: Shadow Lake, ninth installment in the Mystery Case Files series by Big Fish Studios.
She was also seen as Alex in 2014 American drama film 50 to 1, based on the true story of Mine That Bird, an undersized thoroughbred racehorse who won the 2009 Kentucky Derby. She won "Best Lead Actress" award for her role Ms. Hoog in Painted Horses at International Christian Film Festival 2017. She will be seen alongside her sister Zoey Deutch in her mother's directorial debut The Year Of Spectacular Men. She will portray a young woman fresh out of college as she strikes up and torches relationships with several men, including characters played by Jesse Bradford and Nicholas Braun. She has also written the script of The Year Of Spectacular Men.