John R. Vane

About John R. Vane

Who is it?: Pharmacologist
Birth Day: March 29, 1927
Birth Place: Tardebigge, Worcestershire, British
Died On: 19 November 2004(2004-11-19) (aged 77)\nKent
Birth Sign: Aries
Citizenship: British
Alma mater: University of Birmingham (BSc) University of Oxford (DPhil)
Known for: Aspirin Prostaglandin
Spouse(s): Elizabeth Daphne Page (m. 1948)
Awards: FRS (1974) Nobel Prize in Physiology or Medicine (1982) Royal Medal (1989) Lasker Award (1977)
Fields: Pharmacology
Institutions: University of London Yale University
Thesis: Blood flow and its relation to secretion in the stomach and smaller intestine (1952)
Doctoral advisor: Geoffrey S. Dawes

John R. Vane Net Worth

John R. Vane was bornon March 29, 1927 in Tardebigge, Worcestershire, British, is Pharmacologist. Sir John Robert Vane was an eminent British pharmacologist of the twentieth century who received the Nobel Prize in Physiology or Medicine for his work on prostaglandins and the active biological substances that were related with it. He shared the prize with two other scientists, Bengt Samuelsson and Sune Bergstrom. His discovery on the effects of aspirin in relieving pain and inflammation led to new methods of treatment of heart diseases and problems with blood vessels. Though aspirin had been used for many years to relieve pain, nobody understood how it worked. He was the first to discover that aspirin was able to reduce the production of some of the ‘prostaglandins’ which were responsible for creating inflammation, pain and fever in the body. He explained how aspirin prevented blood clotting and strokes and heart attacks. He developed a set of ‘bioassay’ or ‘biological assessment’ techniques to measure the activity of a biological substance in measuring the effect of ‘angiotensin-converting enzymes’. With the help of these techniques he was able to establish a link between ‘prostaglandins’ and aspirin. He was also instrumental in the development of ‘prostacyclin’ which is a key factor in helping the blood vessels remain healthy.
John R. Vane is a member of Scientists

💰 Net worth: Under Review

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Awards and nominations:

Vane was elected a Fellow of the Royal Society (FRS) in 1974. He was also awarded honorary doctorate degrees from Jagiellonian University Medical College (formerly Copernicus Academy of Medicine) in 1977, Paris Descartes University in 1978, Mount Sinai School of Medicine in 1980 and the University of Aberdeen in 1983. He was awarded the Lasker Award in 1977 for the discovery of prostacyclin and was knighted in 1984 for his contributions to science.

Biography/Timeline

1944

Born in Tardebigge, Worcestershire, John Vane was one of three children and grew up in suburban Birmingham. His father, Maurice Vane, was the son of Jewish Russian immigrants and his mother, Frances Vane, came from a Worcestershire farming family. He attended a local state school from age 5, before moving on to King Edward's School in Edgbaston, Birmingham. An early interest in chemistry was to prove the inspiration for studying the subject at the University of Birmingham in 1944.

1946

During his undergraduate studies, Vane became disenchanted with chemistry but still enjoyed experimentation. When Maurice Stacey, the Professor of Chemistry at Birmingham, was asked by Harold Burn to recommend a student to go to Oxford and study pharmacology, Vane jumped at the chance and moved to Burn's department in 1946. Under Burn's guidance, Vane found motivation and enthusiasm for pharmacology, writing: "[the] laboratory gradually became the most active and important centre for pharmacological research in the U.K. and the main school for training of young pharmacologists." Vane completed a Bachelor of Science degree in pharmacology and briefly went to work at the University of Sheffield, before coming back to Oxford to complete his Doctor of Philosophy degree in 1953 supervised by Geoffrey Dawes.

1955

After completing his DPhil, Vane worked as an assistant professor the Department of Pharmacology at Yale University before moving back to the United Kingdom to take up a post as a senior lecturer in the Institute of Basic Medical Sciences at the University of London in 1955.

1966

Vane held a post at the University of London for 18 years, progressing from senior lecturer to Professor of Experimental Pharmacology in 1966 (at the Royal College of Surgeons). During that time he developed certain bioassay techniques and focussed his research on both angiotensin-converting enzyme and the actions of aspirin, eventually leading to the publication with Priscilla Piper of the relationship between aspirin and the prostaglandins that earned him the Nobel Prize in Physiology or Medicine in 1982.

1973

In 1973, Vane left his academic post at the Royal College of Surgeons and took up the position as Director of Research at the Wellcome Foundation, taking a number of his colleagues with him who went on to form the Prostaglandin Research department. Under the leadership of Salvador Moncada, this group continued important research that eventually led to the discovery of prostacyclin.

1974

Vane was elected a Fellow of the Royal Society (FRS) in 1974. He was also awarded honorary doctorate degrees from Jagiellonian University Medical College (formerly Copernicus Academy of Medicine) in 1977, Paris Descartes University in 1978, Mount Sinai School of Medicine in 1980 and the University of Aberdeen in 1983. He was awarded the Lasker Award in 1977 for the discovery of prostacyclin and was knighted in 1984 for his contributions to science.

1985

In 1985, Vane returned to academic life and founded the william Harvey Research Institute at the Medical College of St Bartholomew's Hospital (now Barts and The London School of Medicine and Dentistry an institution of Queen Mary University of London). At the william Harvey Research Institute, Vane's work focused on selective inhibitors of COX-2, and the interplay between nitric oxide and endothelin in the regulation of vascular function.

2004

John Vane married in 1948 to Elizabeth Daphne Page and had 2 daughters. He died on 19 November 2004 in Princess Royal University Hospital, Kent, from long-term complications arising from leg and hip fractures he sustained in May of that year.