She worked in an office and in a sandwich shop before beginning her career as a radio and TV host.
She and Kyle Sandilands co-hosted a popular radio show called the Kyle and Jackie O Show.
She and her then-husband, Phil O'Neil, co-hosted a 1990s show called Ground Zero. She later had a daughter with her second husband, Lee Henderson, whom she married in 2003.
She was criticized by Australian Prime Minister, Kevin Rudd, for her insensitive on-air comments to a teenage rape victim.