After graduating from Lewis & Clark in 1996, she returned to Los Angeles and appeared in several television shows including Diagnosis: Murder, Tracey Takes On..., and The Sentinel. In 1998, she received her first recurring guest role as Rosalie, a love interest on Party of Five. She appeared as Pepper, a ditzy assistant on Veronica's Closet. In 2003, she got her first regular series role on Lucky, an FX drama about a professional poker player living in Las Vegas.
She starred in the film Dead & Breakfast and has appeared in films such as Bubble Boy, Jay and Silent Bob Strike Back, and Lucky 13. She appeared on the show Once and Again from 2001 to 2002, and on Commander in Chief from 2005 to 2006. She has had recurring guest roles on the shows Major Crimes (as Rusty's biological mother), Veronica's Closet, Party of Five, and Women's Murder Club. She has also appeared in television shows such as House, Law & Order: Criminal Intent, CSI, Will & Grace, Just Shoot Me!, and 24.
In 2008, she was a judge at the 2nd annual Noor Iranian Film Festival.
Carradine and husband Coby Brown welcomed a daughter, Chaplin Haddow Brown, on August 9, 2010.. In 2015 they welcomed their second child, a son, Samuel.