I never do anything half-way -- if I'm invested I'm all the way in.
Wynn was born to a middle-class Jewish family on April 28, 1942 in New York City. She graduated from George Washington University, where she received a bachelor of arts degree in Political Science in 1964.
Wynn co-founded the Mirage Resorts with her former husband in 1976. They also co-founded Wynn Resorts in 2000. She served on its board of Directors. She played a pivotal role in the resurgence and expansion of the Las Vegas Strip with her former husband. In 2015, she nominated herself to the board, but she was not confirmed.
Wynn was married to businessman Steve Wynn. They divorced in 2009. Wynn currently resides in the couple's mansion inside Southern Highlands Golf Club.
Currently, she serves on the National Board of Directors of Communities in Schools, a non-profit organization which supports financially disadvantaged schoolchildren. She was appointed to Nevada's Blue Ribbon Education Reform Task Force in 2011, and on Nevada's State Board of Education in 2013 and 2015. Moreover, she was appointed to the Board of Trustees of the Kennedy Center for the Performing Arts by President Barack Obama in 2011. She serves as the co-Chair of the Los Angeles County Museum of Art (LACMA).
Wynn is an avid art collector. In 2013, she acquired Francis Bacon's Three Studies of Lucian Freud for a US$142.4 million, and loaned it to the Portland Art Museum.