Edwin G. Krebs

About Edwin G. Krebs

Who is it?: Biochemist
Birth Day: June 06, 1918
Birth Place: Lansing, Iowa, United States, United States
Died On: December 21, 2009(2009-12-21) (aged 91)\nSeattle, Washington
Birth Sign: Cancer
Alma mater: University of Illinois at Urbana-Champaign (B.S.), Washington University in St. Louis (M.D.)
Awards: Louisa Gross Horwitz Prize (1989) Welch Award in Chemistry (1991) Nobel Prize in Physiology or Medicine (1992)
Fields: biochemistry
Institutions: University of Washington, Seattle University of California, Davis

Edwin G. Krebs Net Worth

Edwin G. Krebs was bornon June 06, 1918 in Lansing, Iowa, United States, United States, is Biochemist. Edwin G. Krebs was a noted American biochemist, who, along with Edmond H. Fischer, won the 1992 Nobel Prize in Physiology or Medicine. Krebs lost his father when he was only fifteen years old and the incident had a sad repercussion on his otherwise happy childhood. He started thinking what to do with his life even when he was a high school student. Ultimately, he entered the Washington University School of Medicine and earned his medical degrees at the age of twenty five. After a short military service, he was drawn to basic research and joined University of Washington, Seattle as an Assistant Professor at the Department of Biochemistry. There with Edmond H. Fischer, he began to work on enzymology of phosphorylase and within a short time, discovered a biochemical process called reversible protein phosphorylation, which earned them the coveted Nobel Prize many years later. Later, they worked separately on different aspect of the process. He was blessed with a keen intellect. His amazing research output earned him an iconic status among his the scientific fraternity. He was also a loving mentor to numerous students and postdoctoral fellows. Many of them still remember him as a kind and gentle mentor.
Edwin G. Krebs is a member of Scientists

💰 Net worth: Under Review

Some Edwin G. Krebs images

Biography/Timeline

1900

Edwin Krebs is not to be confused with Hans Adolf Krebs (1900–1981), who was also a Nobel Prize–winning biochemist and who discovered the citric acid cycle, which is also known as the Krebs cycle.

1933

Krebs was born in Lansing, Iowa, the third child of william Carl Krebs, a Presbyterian minister and Louise Helen (Stegeman) Krebs. The family moved frequently due to the nature of his father's work, though they settled in Greenville, Illinois when Krebs was six and remained there until his father's unexpected death in 1933. Louise Krebs decided to move her family to Urbana, Illinois, where Krebs's elder brothers were attending the University of Illinois at Urbana-Champaign. Krebs attended Urbana High School, and enrolled at the University of Illinois at Urbana-Champaign in 1936. In his fourth year of study Krebs had decided to either pursue a higher degree in organic chemistry or study Medicine. Receiving a scholarship to attend Washington University School of Medicine in St. Louis, he chose the latter.

1943

The School of Medicine afforded Krebs the opportunity to train as a physician as well as to gain experience in medical research. Following graduation in 1943, he undertook an 18-month residency at Barnes Hospital in St. Louis and then went on active duty as a medical officer in the Navy. Krebs was discharged from the Navy in 1946 and was unable to immediately return to hospital work; he was advised to study basic science instead. He chose to study biochemistry and was postdoctoral fellow to Carl and Gerty Cori, working on the interaction of protamine with rabbit muscle phosphorylase. At the completion of his two years' study, Krebs decided to continue his career as a biochemist.

1948

In 1948 Krebs accepted a position as assistant professor of biochemistry at the University of Washington, Seattle. When Edmond H. Fischer arrived at the Department in 1953, the pair decided to work on the enzymology of phosphorylase. During the course of their study they were able to observe the mechanism by which interconversion of the two forms of phosphorylase takes place: reversible protein phosphorylation.

1977

Krebs's interest in teaching and administration led him to leave the University of Washington to become the founding chairman of the Department of Biochemistry at the University of California, Davis. In 1977 he returned to the University of Washington as Chairman of the Department of Pharmacology.

1992

Explained simply, in reversible protein phosphorylation a protein kinase takes a phosphate group from adenosine triphosphate (ATP) and attaches it to a specific site on a protein, introducing both extra mass and negative charge at that site. This can alter the protein's shape and turn its function in a biological process up or down, either by changing its activity or its ability to bind to another protein. The protein can be converted back to its original state by a protein phosphatase that removes the phosphate. This cycle controls numerous metabolic processes, and plays a central role in the regulation of cell division, shape, and motility. Derangement of specific protein phosphorylation pathways is important in human disease, including cancer and diabetes. Fischer and Krebs were awarded the Nobel Prize for Physiology or Medicine in 1992 for the discovery of reversible protein phosphorylation, .

2009

Krebs died on December 21, 2009. He is survived by his wife Virginia and three children.