She faced Yoko Takahashi on October 4, 2008, at EliteXC: Heat. She won the fight by unanimous decision.
She fought Gina Carano on August 15, 2009, at Strikeforce: Carano vs. Cyborg for the Women's Featherweight Championship. Cyborg won via TKO at 4:59 of the 5:00 first round. The card was the first time that a major promotion had featured a main event between women. After the match, she hugged Carano, and stated in her interview that she had the utmost respect for Carano, and that it was an honor to fight her.
On April 7, 2010, Coker stated that Cyborg would fight again in June. She faced Jan Finney at Strikeforce: Fedor vs. Werdum and won the fight via KO in the second round. Her contract with Strikeforce expired on June 26, 2011. She renewed her Strikeforce contract on August 25, 2011.
Cyborg was married to MMA fighter Evangelista "Cyborg" Santos, and "adopted" his nickname. The couple split in December 2011. She is a naturalized U.S. citizen, since late 2016.
She returned to Muay Thai to face Jennifer Colomb at Lion Fight 11 in Las Vegas on September 20, 2013, defeating the previously undefeated Frenchwoman by TKO in round three. She had initially been set to fight Martina Jindrova but Jindrova withdrew with injury.
She lost a five-round unanimous decision against Jorina Baars in a fight for the inaugural Lion Fight Women's Welterweight Championship in the co-main event of Lion Fight 14 in Las Vegas, Nevada, United States on March 28, 2014. Baars officially knocked down Cyborg in the first round with a head kick and in the fifth round with a spinning heel kick, although Referee Tony Weeks missed at least two other occasions throughout the fight where a knockdown could have been issued. Cyborg hit the canvas from a front kick in one occasion and from a knee on another, both times they were ruled slips by the Referee.
In March 2015, it was announced that Cyborg had signed with the UFC. Cyborg made her promotional debut at UFC 198 against Leslie Smith at a catchweight of 140 pounds. She won the fight by TKO in the first round.
Cyborg faced promotional newcomer Lina Länsberg in a catchweight (140 lb) bout on September 24, 2016, at UFC Fight Night 95. The Referee stopped the fight midway through the second round after Länsberg could not effectively defend herself.
In the first defense of her title, Cyborg faced Holly Holm on December 30, 2017 in the main event at UFC 219. She won the fight via unanimous decision. This win also earned her her first Fight of the Night bonus.
Cyborg faced former Invicta bantamweight champion, Yana Kunitskaya, on March 3, 2018, at UFC 222 for her second featherweight title defense. Cyborg won the fight by TKO in the first round.